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Original illustration for VIP research notes: abstract molecular artwork in orange and teal
Original illustration by USA Peptide Vendors; artistic, not a structural model.

Growth & signaling research peptides

VIP research guide in four steps

28-residue neuropeptide of the secretin/glucagon family. VIP was isolated from small intestine in 1970 as a potent vasodilator and acts through the VPAC1 and VPAC2 receptors.

Growth28 residuesVasoactive intestinal peptideUpdated 2026-11-09

  1. Confirm what VIP is

    Amino acid sequence · 28 residues
    1. H1
    2. S2
    3. D3
    4. A4
    5. V5
    6. F6
    7. T7
    8. D8
    9. N9
    10. Y10
    11. T11
    12. R12
    13. L13
    14. R14
    15. K15
    16. Q16
    17. M17
    18. A18
    19. V19
    20. K20
    21. K21
    22. Y22
    23. L23
    24. N24
    25. S25
    26. I26
    27. L27
    28. N28

    Native VIP is C-terminally amidated. PubChem's aviptadil record lists the free acid instead, so we don't show a single formula or CAS number.

    Length
    28 residues

    Verified 2026-11-09 against UniProt P01282. Values we couldn't verify are left out.

  2. Know the proposed mechanism

    VIP was isolated from small intestine in 1970 as a potent vasodilator and acts through the VPAC1 and VPAC2 receptors.

    Mechanism map

    Evidence level: Classic isolation study and receptor nomenclature. All mechanism maps

    VIP mechanism diagramVPAC receptor signaling and vasodilation. Targets: VPAC1, VPAC2. Signaling: Gαs → cAMP ↑. Effects reported: Vasodilation, Blood pressure ↓.VIP mechanism mapVPAC receptor signaling and vasodilationVIP28-residue neuropeptideVPAC1[2]VPAC2[2]Gαs[2]cAMP ↑[2]Vasodilation[1]Blood pressure ↓dogs [1]Evidence: Classic isolation study and receptor nomenclature. Numbers in brackets refer tothe cited sources.usapeptidevendors.com · Research Use OnlyRECEPTORSSIGNALINGEFFECTS REPORTED
    VIP also binds the PAC1 receptor weakly; effects depend on tissue receptor mix. Open SVG
    1. Said SI et al. Polypeptide with broad biological activity: isolation from small intestine. Science. 1970;169:1217-8.
    2. Harmar AJ et al. International Union of Pharmacology. XVIII. Nomenclature of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide. Pharmacol Rev. 1998;50:265-70.

  3. Compare two documented suppliers

  4. Verify the lot before use

FAQ

What is VIP?

28-residue neuropeptide of the secretin/glucagon family. VIP was isolated from small intestine in 1970 as a potent vasodilator and acts through the VPAC1 and VPAC2 receptors.

Where can US labs buy VIP?

Purgo Labs stocks it as “VIP”; code usapeptidevendors takes 25% off at checkout. This page also lists the best-documented second vendor from our 112-vendor directory.

Is research-grade VIP for human use?

No. Vendor material is sold for Research Use Only, not for human or veterinary use.