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Skin & melanocortin research peptides

GHK-Cu — sequence, sources and suppliers

Copper(II) complex of the tripeptide Gly-His-Lys. GHK-Cu stimulated collagen synthesis in fibroblast culture in 1988 and has since been studied in wound and skin models.

Skin & MelanocortinCAS 89030-95-53 residuesCopper tripeptide-1Prezatide copperGHKCU (Purgo label)Updated 2026-11-09
Original illustration for GHK-Cu research notes: abstract molecular artwork in orange and teal
Original illustration by USA Peptide Vendors; artistic, not a structural model.

At a glance

Amino acid sequence · 3 residues
  1. G1
  2. H2
  3. K3
CAS number
89030-95-5
Molecular formula
C14H23CuN6O4+
Molecular weight
402.92 g/mol
PubChem CID
71587328
Length
3 residues

Values are PubChem's for the copper complex; the free GHK peptide is C14H24N6O4 (CID 73587).

Verified 2026-11-09 against PubChem CID 71587328 and PubChem CID 73587. Values we couldn't verify are left out.

What the literature covers

GHK-Cu stimulated collagen synthesis in fibroblast culture in 1988 and has since been studied in wound and skin models.

43 of 112 directory vendors list GHK-Cu; 20 name their testing lab.

Proposed GHK-Cu signaling

Evidence level: Preclinical: cell culture and wound models. All mechanism maps

GHK-Cu mechanism diagramCopper delivery and fibroblast gene expression in skin and wound models. Targets: Cu(II) delivery to cells. Reported response: Fibroblast gene expression changes. Effects reported: Collagen synthesis ↑, Wound matrix remodeling.GHK-Cu mechanism mapCopper delivery and fibroblast gene expression in skin and wound modelsGHK-Cucopper tripeptideCu(II) delivery to cells[2]Fibroblast gene expression changes[2]Collagen synthesis ↑fibroblast culture [1]Wound matrix remodelingrat wounds [3]Evidence: Preclinical: cell culture and wound models. Numbers in brackets refer to thecited sources.usapeptidevendors.com · Research Use OnlyPROPOSED ACTIONREPORTED RESPONSEEFFECTS REPORTED
Gene-expression data are largely from database analyses; the copper-delivery model is proposed. Open SVG
  1. Maquart FX et al. Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+. FEBS Lett. 1988;238:343-6.
  2. Pickart L et al. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. Int J Mol Sci. 2018;19.
  3. Siméon A et al. Expression of glycosaminoglycans and small proteoglycans in wounds: modulation by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu(2+). J Invest Dermatol. 2000;115:962-8.

Before you order

  • Match the CAS number on the certificate to 89030-95-5.
  • A 3-residue peptide should show a mass-spec identity near 402.92 g/mol; HPLC purity alone doesn't confirm identity.
  • 43 of the 112 vendors in our directory list GHK-Cu; 20 of those name the lab that tests it.

FAQ

What is GHK-Cu?

Copper(II) complex of the tripeptide Gly-His-Lys. GHK-Cu stimulated collagen synthesis in fibroblast culture in 1988 and has since been studied in wound and skin models.

What are GHK-Cu's CAS number and molecular weight?

CAS 89030-95-5, formula C14H23CuN6O4+, 402.92 g/mol, per PubChem CID 71587328 and PubChem CID 73587. Values are PubChem's for the copper complex; the free GHK peptide is C14H24N6O4 (CID 73587).

Where can US labs buy GHK-Cu?

Purgo Labs stocks it as “GHK-CU”; code usapeptidevendors takes 25% off at checkout. This page also lists the best-documented second vendor from our 112-vendor directory.

Is research-grade GHK-Cu for human use?

No. Vendor material is sold for Research Use Only, not for human or veterinary use.