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GHRH research peptides

CJC-1295

CJC-1295 vendor pages often blur naming between DAC and non-DAC forms. Read labels carefully.

Updated 2026-11-03CJC-1295 without DACMod GRF 1-29 variants
Original illustration for CJC-1295 research notes: abstract molecular artwork in orange and teal

Original illustration by USA Peptide Vendors. Artistic, not a structural model.

Chemistry facts

CAS number
446262-90-4
Molecular formula
C165H269N47O46
Molecular weight
3647.2 g/mol
PubChem CID
91971820

These values are for PubChem's CJC-1295 record, described as a maleimido derivative of hGRF(1-29), the DAC-type construct. No-DAC (Mod GRF 1-29) SKUs are a different material with a different formula and weight. We left the sequence out because we could not verify it against a primary database.

Verified 2026-11-09 against PubChem CID 91971820. Values we could not verify are left out.

How CJC-1295 is thought to work

Evidence level: Clinical pharmacology study and rat studies. See every diagram in the mechanism map library.

CJC-1295 mechanism diagramGHRH receptor agonism and pituitary growth hormone release. Targets: GHRH receptor. Signaling: Gαs → cAMP ↑. Effects reported: GH release ↑, IGF-1 ↑.CJC-1295 mechanism mapGHRH receptor agonism and pituitary growth hormone releaseCJC-1295GHRH(1-29) analogGHRH receptoranterior pituitary somatotrophs [2]Gαs[3]cAMP ↑[3]GH release ↑sustained, healthy adults [1,2]IGF-1 ↑healthy adults [1]Evidence: Clinical pharmacology study and rat studies. Numbers in brackets refer to thecited sources.usapeptidevendors.com · Research Use OnlyRECEPTORSIGNALINGEFFECTS REPORTED
The prolonged-action findings come from the DAC form, which binds albumin [2]. No-DAC (Mod GRF 1-29) SKUs lack that albumin-binding group. Open SVG
  1. Teichman SL et al. Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults. J Clin Endocrinol Metab. 2006;91:799–805.
  2. Jetté L et al. Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats. Endocrinology. 2005;146:3052–3058.
  3. Cunha SR, Mayo KE. Ghrelin and growth hormone (GH) secretagogues potentiate GH-releasing hormone (GHRH)-induced cyclic adenosine 3′,5′-monophosphate production. Endocrinology. 2002;143:4570–4582.

Research context

Directory notes focus on naming clarity, assay presence, and whether vendors separate DAC vs non-DAC SKUs.

Buyer notes

  • Verify DAC vs non-DAC labeling on both product page and COA
  • Prefer vendors that keep distinct SKUs for each form

Related USA vendors

Northbound Research — OpenFile clear

Batch IDs near titles; Midwest shipping language

Atlas Bench Chem — OpenFile clear

PO-friendly, chromatogram-forward

Pine Ridge Peptides — OpenFile conditional

Staple SKUs, lighter long-tail files

FAQ

Why does naming matter for CJC listings?

DAC and non-DAC forms are different research materials. Clear labeling reduces procurement mistakes.

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