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Tissue research peptides

TB-500

TB-500 listings are widespread across USA research catalogs. Compare documentation depth before price alone.

Updated 2026-11-06Thymosin Beta-4 fragment research SKUs
Original illustration for TB-500 research notes: abstract molecular artwork in orange and teal

Original illustration by USA Peptide Vendors. Artistic, not a structural model.

Chemistry facts

Amino acid sequence · 7 residues
  1. L1
  2. K2
  3. K3
  4. T4
  5. E5
  6. T6
  7. Q7

PubChem's TB-500 record is the acetylated 7-residue fragment (thymosin β4 residues 17–23). Some vendors label full-length thymosin β4 as TB-500, so check the COA analyte.

CAS number
885340-08-9
Molecular formula
C38H68N10O14
Molecular weight
889.0 g/mol
PubChem CID
62707662

Verified 2026-11-09 against PubChem CID 62707662. Values we could not verify are left out.

How TB-500 is thought to work

Evidence level: Preclinical, mostly inferred from full-length thymosin β4. See every diagram in the mechanism map library.

TB-500 mechanism diagramActin-binding motif of thymosin β4 and the cytoskeleton. Targets: G-actin. Cytoskeletal effect: G-actin sequestration → Actin pool regulation → Cytoskeletal remodeling. Effects reported (Tβ4 studies): Cell migration, Wound repair.TB-500 mechanism mapActin-binding motif of thymosin β4 and the cytoskeletonTB-500Ac-LKKTETQ (Tβ4 17–23)G-actinmonomer binding (LKKTETQ motif) [1,2]G-actinsequestration[1]Actin poolregulation[1]Cytoskeletalremodeling[2]Cell migration[2]Wound repairanimal models [2]Evidence: Preclinical, mostly inferred from full-length thymosin β4. Numbers in bracketsrefer to the cited sources.usapeptidevendors.com · Research Use OnlyINTRACELLULAR TARGETCYTOSKELETAL EFFECTEFFECTS REPORTED (TΒ4 STUDIES)
Most mechanistic data are for full-length thymosin β4. Data specific to the 7-residue fragment are limited. Open SVG
  1. Huff T et al. β-Thymosins, small acidic peptides with multiple functions. Int J Biochem Cell Biol. 2001;33:205–220.
  2. Goldstein AL et al. Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applications. Expert Opin Biol Ther. 2012;12:37–51.

Research context

Vendor SKUs labeled TB-500 vary in how clearly they disclose sequence, salt form, and assay methods. UPV flags vendors that publish lot-linked PDFs.

Buyer notes

  • Clarify whether the listing discloses sequence/fragment details
  • Compare reconstitution guidance for lab handling only
  • Watch for generic certificates reused across unrelated lots

Related USA vendors

Purgo Labs — OpenFile clear

US catalog with lot notes that usually sit next to the buy button

Lumen Forge Bio — OpenFile hold

Fast restocks, short public history

Pine Ridge Peptides — OpenFile conditional

Staple SKUs, lighter long-tail files

FAQ

Why do TB-500 prices vary so much?

Catalog breadth, assay frequency, shipping model, and promo stacking all move sticker prices. OpenFile grades are separate from price.

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