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Cognitive explainer

What the research says about Selank

Synthetic heptapeptide: the immunomodulatory peptide tuftsin (TKPR) extended with Pro-Gly-Pro.

CognitiveCAS 129954-34-37 residuesTP-7Updated 2026-11-09
Original illustration for Selank research notes: abstract molecular artwork in orange and teal
Original illustration by USA Peptide Vendors; artistic, not a structural model.

What has actually been studied?

Selank was developed in Russia as an anxiolytic. Studies report effects on enkephalin breakdown and on GABA-related gene expression.

How is Selank thought to work?

Evidence level: Limited: in-vitro and cell-line studies. All mechanism maps

Selank mechanism diagramTwo reported actions: slower enkephalin breakdown and changes in GABA-related genes. Targets: Enkephalin-degrading enzymes, GABAergic genes. : . Effects reported: Enkephalin breakdown ↓, Gene-expression changes.Selank mechanism mapTwo reported actions: slower enkephalin breakdown and changes in GABA-relatedgenesSelankTKPRPGPEnkephalin-degrading enzymeshuman plasma [1]GABAergic genesIMR-32 cells [2]Enkephalin breakdown ↓[1]Gene-expression changes[2]Evidence: Limited: in-vitro and cell-line studies. Numbers in brackets refer to the citedsources.usapeptidevendors.com · Research Use OnlyREPORTED TARGETSEFFECTS REPORTED
Most Selank research comes from Russian groups; independent replication is limited. Open SVG
  1. Zolotarev IuA et al. [Leu-enkephalin homogeneously labeled with tritium in studying the Selank inhibiting effect on the enkephalin-degrading enzymes of human plasma]. Bioorg Khim. 2004;30:234-40.
  2. Filatova E et al. GABA, Selank, and Olanzapine Affect the Expression of Genes Involved in GABAergic Neurotransmission in IMR-32 Cells. Front Pharmacol. 2017;8:89.

What does the molecule look like?

Amino acid sequence · 7 residues
  1. T1
  2. K2
  3. P3
  4. R4
  5. P5
  6. G6
  7. P7
  • CAS number129954-34-3
  • Molecular formulaC33H57N11O9
  • Molecular weight751.9 g/mol
  • PubChem CID11765600
  • Length7 residues

Purgo's product data lists C33H57N9O9; PubChem's formula above matches the sequence.

Verified 2026-11-09 against PubChem CID 11765600. Values we couldn't verify are left out.

Where do US labs buy Selank?

41 of 112 directory vendors list Selank; 19 name their testing lab.

What should the certificate show?

  • Match the CAS number on the certificate to 129954-34-3.
  • A 7-residue peptide should show a mass-spec identity near 751.9 g/mol; HPLC purity alone doesn't confirm identity.
  • 41 of the 112 vendors in our directory list Selank; 19 of those name the lab that tests it.

Other questions researchers ask

What is Selank?

Synthetic heptapeptide: the immunomodulatory peptide tuftsin (TKPR) extended with Pro-Gly-Pro. Selank was developed in Russia as an anxiolytic. Studies report effects on enkephalin breakdown and on GABA-related gene expression.

What are Selank's CAS number and molecular weight?

CAS 129954-34-3, formula C33H57N11O9, 751.9 g/mol, per PubChem CID 11765600. Purgo's product data lists C33H57N9O9; PubChem's formula above matches the sequence.

Where can US labs buy Selank?

Purgo Labs stocks it as “Selank”; code usapeptidevendors takes 25% off at checkout. This page also lists the best-documented second vendor from our 112-vendor directory.

Is research-grade Selank for human use?

No. Vendor material is sold for Research Use Only, not for human or veterinary use.