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Skin & melanocortin research peptides

Melanotan II (MT2) — sequence, sources and suppliers

Cyclic α-MSH analogue that activates several melanocortin receptors, including MC1R and MC4R. A 1996 pilot study reported tanning; mouse work used it to show MC4R's role in feeding.

Skin & MelanocortinCAS 121062-08-6MT-IIUpdated 2026-11-09
Original illustration for Melanotan II (MT2) research notes: abstract molecular artwork in orange and teal
Original illustration by USA Peptide Vendors; artistic, not a structural model.

At a glance

Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2: a lactam ring joins the Asp and Lys side chains.

CAS number
121062-08-6
Molecular formula
C50H69N15O9
Molecular weight
1024.2 g/mol
PubChem CID
92432

Verified 2026-11-09 against PubChem CID 92432. Values we couldn't verify are left out.

What the literature covers

A 1996 pilot study reported tanning; mouse work used it to show MC4R's role in feeding.

34 of 112 directory vendors list Melanotan II; 19 name their testing lab.

Proposed Melanotan II signaling

Evidence level: Pilot human study and mouse studies. All mechanism maps

Melanotan II mechanism diagramAgonist at MC1R (pigmentation) and MC4R (appetite, sexual function). Targets: MC1R, MC4R. : . Effects reported: Skin tanning, Food intake ↓.Melanotan II mechanism mapAgonist at MC1R (pigmentation) and MC4R (appetite, sexual function)Melanotan IIcyclic α-MSH analogueMC1Rmelanocytes [1]MC4Rhypothalamus [2]Skin tanningpilot phase 1 [1]Food intake ↓mice [2]Evidence: Pilot human study and mouse studies. Numbers in brackets refer to the citedsources.usapeptidevendors.com · Research Use OnlyRECEPTORSEFFECTS REPORTED
The pilot study also reported nausea and spontaneous erections, consistent with MC4R activity. Open SVG
  1. Dorr RT et al. Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study. Life Sci. 1996;58:1777-84.
  2. Fan W et al. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature. 1997;385:165-8.

Before you order

  • Purgo sells it as “MT2”. Make sure the COA names the analyte, not just the store label.
  • Match the CAS number on the certificate to 121062-08-6.
  • 34 of the 112 vendors in our directory list Melanotan II; 19 of those name the lab that tests it.
  • Purgo markets MT2 for “circadian rhythm and sleep research”, but its product data gives Melanotan II's CAS number. Melanotan II is a melanocortin agonist, not a melatonin analogue.

FAQ

What is Melanotan II (MT2)?

Cyclic α-MSH analogue that activates several melanocortin receptors, including MC1R and MC4R. A 1996 pilot study reported tanning; mouse work used it to show MC4R's role in feeding.

What are Melanotan II (MT2)'s CAS number and molecular weight?

CAS 121062-08-6, formula C50H69N15O9, 1024.2 g/mol, per PubChem CID 92432.

Where can US labs buy Melanotan II (MT2)?

Purgo Labs stocks it as “MT2”; code usapeptidevendors takes 25% off at checkout. This page also lists the best-documented second vendor from our 112-vendor directory.

Is research-grade Melanotan II (MT2) for human use?

No. Vendor material is sold for Research Use Only, not for human or veterinary use.