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Original illustration for Kisspeptin-10 research notes: abstract molecular artwork in orange and teal
Original illustration by USA Peptide Vendors; artistic, not a structural model.

Growth & signaling research peptides

Kisspeptin-10 research guide in four steps

C-terminal decapeptide of kisspeptin, the natural ligand of the KISS1 receptor (GPR54). Kisspeptin directly stimulates GnRH release, which places it at the top of the reproductive hormone axis.

GrowthCAS 374675-21-510 residuesKP-10Metastin (45-54)Updated 2026-11-09

  1. Confirm what Kisspeptin-10 is

    Amino acid sequence · 10 residues
    1. Y1
    2. N2
    3. W3
    4. N4
    5. S5
    6. F6
    7. G7
    8. L8
    9. R9
    10. F10
    CAS number
    374675-21-5
    Molecular formula
    C63H83N17O14
    Molecular weight
    1302.4 g/mol
    PubChem CID
    25240297
    Length
    10 residues

    Verified 2026-11-09 against PubChem CID 25240297. Values we couldn't verify are left out.

  2. Know the proposed mechanism

    Kisspeptin directly stimulates GnRH release, which places it at the top of the reproductive hormone axis.

    Mechanism map

    Evidence level: Preclinical: receptor identification and mouse studies. All mechanism maps

    Kisspeptin-10 mechanism diagramKISS1R (GPR54) activation drives GnRH release. Targets: KISS1R. Signaling reported: GnRH neurons → GnRH release ↑. Effect reported: LH secretion ↑.Kisspeptin-10 mechanism mapKISS1R (GPR54) activation drives GnRH releaseKisspeptin-10KP-10 decapeptideKISS1RGPR54 [1,2]GnRH neurons[2]GnRH release ↑[2]LH secretion ↑mice [2]Evidence: Preclinical: receptor identification and mouse studies. Numbers in brackets referto the cited sources.usapeptidevendors.com · Research Use OnlyRECEPTORSIGNALING REPORTEDEFFECT REPORTED
    KP-10 is the shortest fully active kisspeptin fragment; longer forms share the receptor. Open SVG
    1. Kotani M et al. The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J Biol Chem. 2001;276:34631-6.
    2. Messager S et al. Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54. Proc Natl Acad Sci U S A. 2005;102:1761-6.

  3. Compare two documented suppliers

    33 of 112 directory vendors list Kisspeptin; 14 name their testing lab.

  4. Verify the lot before use

    1. Purgo sells it as “Kisspeptin”. Make sure the COA names the analyte, not just the store label.
    2. Match the CAS number on the certificate to 374675-21-5.
    3. A 10-residue peptide should show a mass-spec identity near 1302.4 g/mol; HPLC purity alone doesn't confirm identity.
    4. 33 of the 112 vendors in our directory list Kisspeptin; 14 of those name the lab that tests it.

FAQ

What is Kisspeptin-10?

C-terminal decapeptide of kisspeptin, the natural ligand of the KISS1 receptor (GPR54). Kisspeptin directly stimulates GnRH release, which places it at the top of the reproductive hormone axis.

What are Kisspeptin-10's CAS number and molecular weight?

CAS 374675-21-5, formula C63H83N17O14, 1302.4 g/mol, per PubChem CID 25240297.

Where can US labs buy Kisspeptin-10?

Purgo Labs stocks it as “Kisspeptin”; code usapeptidevendors takes 25% off at checkout. This page also lists the best-documented second vendor from our 112-vendor directory.

Is research-grade Kisspeptin-10 for human use?

No. Vendor material is sold for Research Use Only, not for human or veterinary use.