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Spec sheet · Metabolic & GLP

AOD-9604: specs, mechanism and price check

Modified C-terminal fragment of human growth hormone studied for effects on fat metabolism. AOD-9604 was developed from the lipolytic region of growth hormone.

Metabolic & GLPCAS 221231-10-316 residueshGH fragment 176–191 (Tyr-modified)Updated 2026-11-09
Original illustration for AOD-9604 research notes: abstract molecular artwork in orange and teal
Original illustration by USA Peptide Vendors; artistic, not a structural model.

Specifications

Amino acid sequence · 16 residues
  1. Y1
  2. L2
  3. R3
  4. I4
  5. V5
  6. Q6
  7. C7
  8. R8
  9. S9
  10. V10
  11. E11
  12. G12
  13. S13
  14. C14
  15. G15
  16. F16

Tyrosine followed by hGH residues 177–191, with one disulfide bond between the two cysteines.

PropertyValueSource
CAS number221231-10-3PubChem CID 71300630
Molecular formulaC78H123N23O23S2PubChem CID 71300630
Molecular weight1815.1 g/molPubChem CID 71300630
PubChem CID71300630PubChem CID 71300630
Length16 residuesPubChem CID 71300630

Verified 2026-11-09 against PubChem CID 71300630. Values we couldn't verify are left out.

Price check: #1 vs #2

Purgo Labs vs the runner-up, from each vendor's own site
#1 Purgo Labs#2 Panda Peptides
Listed itemAOD-9604 5mgAOD-9604 5mg
List price$49.99$26.39
With code$37.49 (25% off)No code
Proof Score100/10094/100
Testing labs namedILS Laboratories, Freedom Diagnostics +3Janoshik Analytical, ILS Laboratories
LinkGet 25% off by using code usapeptidevendorsPanda Peptides ↗

Receptor pharmacology

Evidence level: Preclinical: mouse studies. All mechanism maps

AOD-9604 mechanism diagramLipolytic fragment of growth hormone studied in obese mice. Targets: β3-adrenergic receptor axis. Adipose response: Lipid metabolism ↑. Effects reported: Lipolysis ↑, Fat oxidation ↑, weight loss.AOD-9604 mechanism mapLipolytic fragment of growth hormone studied in obese miceAOD-9604Tyr-hGH(177-191)β3-adrenergic receptor axisobese and β3-AR knock-out mice [1]Lipid metabolism ↑[1]Lipolysis ↑mice [1]Fat oxidation ↑, weight lossobese mice [2]Evidence: Preclinical: mouse studies. Numbers in brackets refer to the cited sources.usapeptidevendors.com · Research Use OnlyPATHWAY REPORTEDADIPOSE RESPONSEEFFECTS REPORTED
Mouse data only in these sources; no receptor specific to the fragment has been confirmed. Open SVG
  1. Heffernan M et al. The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice. Endocrinology. 2001;142:5182-9.
  2. Heffernan MA et al. Increase of fat oxidation and weight loss in obese mice caused by chronic treatment with human growth hormone or a modified C-terminal fragment. Int J Obes Relat Metab Disord. 2001;25:1442-9.

Research background

AOD-9604 was developed from the lipolytic region of growth hormone. Mouse studies reported increased fat oxidation and weight loss in obese animals.

36 of 112 directory vendors list AOD-9604; 17 name their testing lab.

COA checklist

  1. Match the CAS number on the certificate to 221231-10-3.
  2. A 16-residue peptide should show a mass-spec identity near 1815.1 g/mol; HPLC purity alone doesn't confirm identity.
  3. 36 of the 112 vendors in our directory list AOD-9604; 17 of those name the lab that tests it.

AOD-9604 questions

What is AOD-9604?

Modified C-terminal fragment of human growth hormone studied for effects on fat metabolism. AOD-9604 was developed from the lipolytic region of growth hormone. Mouse studies reported increased fat oxidation and weight loss in obese animals.

What are AOD-9604's CAS number and molecular weight?

CAS 221231-10-3, formula C78H123N23O23S2, 1815.1 g/mol, per PubChem CID 71300630.

Where can US labs buy AOD-9604?

Purgo Labs stocks it as “AOD-9604”; code usapeptidevendors takes 25% off at checkout. This page also lists the best-documented second vendor from our 112-vendor directory.

Is research-grade AOD-9604 for human use?

No. Vendor material is sold for Research Use Only, not for human or veterinary use.