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Spec sheet · Metabolic & GLP

Exenatide: specs, mechanism and price check

39-residue GLP-1 receptor agonist first isolated from Gila monster venom as exendin-4. Exendin-4 was found to be a high-potency agonist at the GLP-1 receptor in the early 1990s.

Metabolic & GLPCAS 141758-74-939 residuesExendin-4Exana (Purgo spray)Updated 2026-11-09
Original illustration for Exenatide research notes: abstract molecular artwork in orange and teal
Original illustration by USA Peptide Vendors; artistic, not a structural model.

Specifications

Amino acid sequence · 39 residues
  1. H1
  2. G2
  3. E3
  4. G4
  5. T5
  6. F6
  7. T7
  8. S8
  9. D9
  10. L10
  11. S11
  12. K12
  13. Q13
  14. M14
  15. E15
  16. E16
  17. E17
  18. A18
  19. V19
  20. R20
  21. L21
  22. F22
  23. I23
  24. E24
  25. W25
  26. L26
  27. K27
  28. N28
  29. G29
  30. G30
  31. P31
  32. S32
  33. S33
  34. G34
  35. A35
  36. P36
  37. P37
  38. P38
  39. S39
PropertyValueSource
CAS number141758-74-9PubChem CID 45588096
Molecular formulaC184H282N50O60SPubChem CID 45588096
Molecular weight4187 g/molPubChem CID 45588096
PubChem CID45588096PubChem CID 45588096
Length39 residuesPubChem CID 45588096

Verified 2026-11-09 against PubChem CID 45588096. Values we couldn't verify are left out.

Price check: #1 vs #2

Purgo Labs vs the runner-up, from each vendor's own site
#1 Purgo Labs#2 Idun Peptides
Listed itemExana (GLP Spray) 5mg / 15mL (100 Sprays)Doesn't list this exact item; best-documented vendor in our directory
List price$79.99—
With code$59.99 (25% off)No code
Proof Score100/100100/100
Testing labs namedILS Laboratories, Freedom Diagnostics +3Kovera Labs, Freedom Diagnostics
LinkGet 25% off by using code usapeptidevendorsIdun Peptides ↗

Receptor pharmacology

Evidence level: Preclinical receptor pharmacology. All mechanism maps

Exenatide mechanism diagramHigh-potency agonist at the GLP-1 receptor, first found in Gila monster venom. Targets: GLP-1R. Signaling measured: cAMP ↑. Effects reported: β-cell cAMP response, Pancreatic acinar response.Exenatide mechanism mapHigh-potency agonist at the GLP-1 receptor, first found in Gila monster venomExenatideexendin-4, 39 residuesGLP-1Rinsulin-secreting β-cells [2]cAMP ↑[1,2]β-cell cAMP responseinsulinoma cells [2]Pancreatic acinar responseguinea pig [1]Evidence: Preclinical receptor pharmacology. Numbers in brackets refer to the citedsources.usapeptidevendors.com · Research Use OnlyRECEPTORSIGNALING MEASUREDEFFECTS REPORTED
Purgo sells exenatide only as a ready-mixed spray; the cited work used dissolved peptide in cell assays. Open SVG
  1. Eng J et al. Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas. J Biol Chem. 1992;267:7402-5.
  2. Göke R et al. Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells. J Biol Chem. 1993;268:19650-5.

Research background

Exendin-4 was found to be a high-potency agonist at the GLP-1 receptor in the early 1990s. Purgo's only listing is “Exana”, a ready-mixed 5mg / 15mL spray (100 sprays).

COA checklist

  1. Purgo sells it as “Exana (GLP Spray)”. Make sure the COA names the analyte, not just the store label.
  2. Match the CAS number on the certificate to 141758-74-9.
  3. A 39-residue peptide should show a mass-spec identity near 4187 g/mol; HPLC purity alone doesn't confirm identity.
  4. Purgo's product name is “Exana (GLP Spray)” and does not say exenatide; its product handle does. Confirm the analyte on the COA.

Exenatide questions

What is Exenatide?

39-residue GLP-1 receptor agonist first isolated from Gila monster venom as exendin-4. Exendin-4 was found to be a high-potency agonist at the GLP-1 receptor in the early 1990s. Purgo's only listing is “Exana”, a ready-mixed 5mg / 15mL spray (100 sprays).

What are Exenatide's CAS number and molecular weight?

CAS 141758-74-9, formula C184H282N50O60S, 4187 g/mol, per PubChem CID 45588096.

Where can US labs buy Exenatide?

Purgo Labs stocks it as “Exana (GLP Spray)”; code usapeptidevendors takes 25% off at checkout. This page also lists the best-documented second vendor from our 112-vendor directory.

Is research-grade Exenatide for human use?

No. Vendor material is sold for Research Use Only, not for human or veterinary use.