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Original illustration for 5-Amino-1MQ research notes: abstract molecular artwork in orange and teal
Original illustration by USA Peptide Vendors; artistic, not a structural model.

Bench sheet · Small molecule

5-Amino-1MQ: bench notes and specs

Small-molecule inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT). It is not a peptide. Quinolinium NNMT inhibitors were reported in 2018 to raise NAD+ in fat cells and reduce weight gain in diet-induced obese mice.

Metabolic & GLPCAS 685079-15-65-Amino-1-methylquinoliniumUpdated 2026-11-09
  1. 01

    What's in it

    Small-molecule inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT). It is not a peptide.

    Quinolinium NNMT inhibitors were reported in 2018 to raise NAD+ in fat cells and reduce weight gain in diet-induced obese mice. Purgo calls it a peptide; chemically it is a small quaternary cation.

  2. 02

    Reference values

    • CAS number685079-15-6
    • Molecular formulaC10H11N2+
    • Molecular weight159.21 g/mol
    • PubChem CID950107

    Formula and weight are for the cation alone, as PubChem lists them.

    Verified 2026-11-09 against PubChem CID 950107. Values we couldn't verify are left out.

  3. 03

    Handling and paperwork

    • Check which salt the COA reports; the active species is a cation and is usually supplied with a counter-ion such as iodide
    • Match the CAS number on the certificate to 685079-15-6.
    • Identity testing should match C10H11N2+ (159.21 g/mol).
  4. 04

    Sourcing

Biochemistry

Evidence level: Preclinical: adipocytes and obese mice. All mechanism maps

5-Amino-1MQ mechanism diagramNNMT inhibition raises NAD+ and SAM in fat cells. Targets: NNMT. Metabolites reported: NAD+ ↑ → SAM ↑. Effects reported: Lipogenesis ↓, Weight and fat mass ↓.5-Amino-1MQ mechanism mapNNMT inhibition raises NAD+ and SAM in fat cells5-Amino-1MQquinolinium small moleculeNNMTnicotinamide N-methyltransferase [1]NAD+ ↑[1]SAM ↑[1]Lipogenesis ↓adipocytes [1]Weight and fat mass ↓diet-induced obese mice [1]Evidence: Preclinical: adipocytes and obese mice. Numbers in brackets refer to the citedsources.usapeptidevendors.com · Research Use OnlyENZYMEMETABOLITES REPORTEDEFFECTS REPORTED
Not a peptide. Data come from one 2018 study in cells and mice. Open SVG
  1. Neelakantan H et al. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice. Biochem Pharmacol. 2018;147:141-152.

FAQ

What is 5-Amino-1MQ?

Small-molecule inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT). It is not a peptide. Quinolinium NNMT inhibitors were reported in 2018 to raise NAD+ in fat cells and reduce weight gain in diet-induced obese mice. Purgo calls it a peptide; chemically it is a small quaternary cation.

What are 5-Amino-1MQ's CAS number and molecular weight?

CAS 685079-15-6, formula C10H11N2+, 159.21 g/mol, per PubChem CID 950107. Formula and weight are for the cation alone, as PubChem lists them.

Where can US labs buy 5-Amino-1MQ?

Purgo Labs stocks it as “5-Amino-1MQ”; code usapeptidevendors takes 25% off at checkout. This page also lists the best-documented second vendor from our 112-vendor directory.

Is research-grade 5-Amino-1MQ for human use?

No. Vendor material is sold for Research Use Only, not for human or veterinary use.