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Longevity explainer

What is PNC-27?

32-residue peptide joining the HDM-2–binding domain of p53 to a membrane-penetrating sequence.

Longevity32 residuesUpdated 2026-11-09
Original illustration for PNC-27 research notes: abstract molecular artwork in orange and teal
Original illustration by USA Peptide Vendors; artistic, not a structural model.

What has actually been studied?

In cell culture PNC-27 binds HDM-2 in cancer-cell membranes and lyses those cells while sparing untransformed cells. Evidence is preclinical.

How is PNC-27 thought to work?

Evidence level: Preclinical: cell culture. All mechanism maps

PNC-27 mechanism diagramBinds HDM-2 in cancer-cell membranes and forms pores. Targets: Membrane HDM-2. Reported: Transmembrane pores. Effects reported: Cancer-cell lysis, Normal cells spared.PNC-27 mechanism mapBinds HDM-2 in cancer-cell membranes and forms poresPNC-27p53(12-26) + penetratinMembrane HDM-2cancer cells [2]Transmembrane pores[2,3]Cancer-cell lysisin vitro [1,2,3]Normal cells sparedin vitro [1]Evidence: Preclinical: cell culture. Numbers in brackets refer to the cited sources.usapeptidevendors.com · Research Use OnlyTARGETREPORTEDEFFECTS REPORTED
Cell-culture data only; not tested in published clinical trials. Open SVG
  1. Kanovsky M et al. Peptides from the amino terminal mdm-2-binding domain of p53, designed from conformational analysis, are selectively cytotoxic to transformed cells. Proc Natl Acad Sci U S A. 2001;98:12438-43.
  2. Sarafraz-Yazdi E et al. Anticancer peptide PNC-27 adopts an HDM-2-binding conformation and kills cancer cells by binding to HDM-2 in their membranes. Proc Natl Acad Sci U S A. 2010;107:1918-23.
  3. Sookraj KA et al. The anti-cancer peptide, PNC-27, induces tumor cell lysis as the intact peptide. Cancer Chemother Pharmacol. 2010;66:325-31.

What does the molecule look like?

Amino acid sequence · 32 residues
  1. P1
  2. P2
  3. L3
  4. S4
  5. Q5
  6. E6
  7. T7
  8. F8
  9. S9
  10. D10
  11. L11
  12. W12
  13. K13
  14. L14
  15. L15
  16. K16
  17. K17
  18. W18
  19. K19
  20. M20
  21. R21
  22. R22
  23. N23
  24. Q24
  25. F25
  26. W26
  27. V27
  28. K28
  29. V29
  30. Q30
  31. R31
  32. G32

p53 residues 12–26 followed by a membrane-residency sequence.

  • Molecular formulaC188H293N53O44S
  • Molecular weight4032 g/mol
  • PubChem CID16201774
  • Length32 residues

Verified 2026-11-09 against PubChem CID 16201774. Values we couldn't verify are left out.

Where do US labs buy PNC-27?

What should the certificate show?

  • A 32-residue peptide should show a mass-spec identity near 4032 g/mol; HPLC purity alone doesn't confirm identity.

Other questions researchers ask

What is PNC-27?

32-residue peptide joining the HDM-2–binding domain of p53 to a membrane-penetrating sequence. In cell culture PNC-27 binds HDM-2 in cancer-cell membranes and lyses those cells while sparing untransformed cells. Evidence is preclinical.

What are PNC-27's CAS number and molecular weight?

formula C188H293N53O44S, 4032 g/mol, per PubChem CID 16201774.

Where can US labs buy PNC-27?

Purgo Labs stocks it as “PNC-27”; code usapeptidevendors takes 25% off at checkout. This page also lists the best-documented second vendor from our 112-vendor directory.

Is research-grade PNC-27 for human use?

No. Vendor material is sold for Research Use Only, not for human or veterinary use.