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Spec sheet · Metabolic & GLP

MOTS-c: specs, mechanism and price check

16-residue peptide encoded within the mitochondrial 12S rRNA gene. MOTS-c was described in 2015 as a mitochondria-derived peptide that acts on the folate cycle and AMPK in mice.

Metabolic & GLPCAS 1627580-64-616 residuesMitochondrial open reading frame of the 12S rRNA-cUpdated 2026-11-09
Original illustration for MOTS-c research notes: abstract molecular artwork in orange and teal
Original illustration by USA Peptide Vendors; artistic, not a structural model.

Specifications

Amino acid sequence · 16 residues
  1. M1
  2. R2
  3. W3
  4. Q4
  5. E5
  6. M6
  7. G7
  8. Y8
  9. I9
  10. F10
  11. Y11
  12. P12
  13. R13
  14. K14
  15. L15
  16. R16
PropertyValueSource
CAS number1627580-64-6PubChem CID 146675088
Molecular formulaC101H152N28O22S2PubChem CID 146675088
Molecular weight2174.6 g/molPubChem CID 146675088
PubChem CID146675088PubChem CID 146675088
Length16 residuesPubChem CID 146675088

Purgo's product data lists a different CAS number and formula; the values here are PubChem's and match the sequence.

Verified 2026-11-09 against PubChem CID 146675088. Values we couldn't verify are left out.

Price check: #1 vs #2

Purgo Labs vs the runner-up, from each vendor's own site
#1 Purgo Labs#2 Idun Peptides
Listed itemMOTS-c 40mgMOTS-c 40mg
List price$124.99$64.99
With code$93.74 (25% off)No code
Proof Score100/100100/100
Testing labs namedILS Laboratories, Freedom Diagnostics +3Kovera Labs, Freedom Diagnostics
LinkGet 25% off by using code usapeptidevendorsIdun Peptides ↗

Receptor pharmacology

Evidence level: Preclinical: cell culture and mice. All mechanism maps

MOTS-c mechanism diagramFolate-cycle inhibition, AICAR build-up and AMPK activation. Targets: Folate cycle. Signaling reported: AICAR ↑ → AMPK activation. Effects reported in mice: Insulin sensitivity ↑, Diet-induced obesity ↓.MOTS-c mechanism mapFolate-cycle inhibition, AICAR build-up and AMPK activationMOTS-cmitochondria-derived peptideFolate cycleinhibited [1]AICAR ↑[1]AMPK activation[1]Insulin sensitivity ↑[1]Diet-induced obesity ↓[1]Evidence: Preclinical: cell culture and mice. Numbers in brackets refer to the citedsources.usapeptidevendors.com · Research Use OnlyTARGET REPORTEDSIGNALING REPORTEDEFFECTS REPORTED IN MICE
Findings come from one founding study and follow-up work in animals. Open SVG
  1. Lee C et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab. 2015;21:443-54.

Research background

MOTS-c was described in 2015 as a mitochondria-derived peptide that acts on the folate cycle and AMPK in mice. Purgo sells a 40mg vial.

46 of 112 directory vendors list MOTS-c; 21 name their testing lab.

COA checklist

  1. Match the CAS number on the certificate to 1627580-64-6.
  2. A 16-residue peptide should show a mass-spec identity near 2174.6 g/mol; HPLC purity alone doesn't confirm identity.
  3. 46 of the 112 vendors in our directory list MOTS-c; 21 of those name the lab that tests it.

MOTS-c questions

What is MOTS-c?

16-residue peptide encoded within the mitochondrial 12S rRNA gene. MOTS-c was described in 2015 as a mitochondria-derived peptide that acts on the folate cycle and AMPK in mice. Purgo sells a 40mg vial.

What are MOTS-c's CAS number and molecular weight?

CAS 1627580-64-6, formula C101H152N28O22S2, 2174.6 g/mol, per PubChem CID 146675088. Purgo's product data lists a different CAS number and formula; the values here are PubChem's and match the sequence.

Where can US labs buy MOTS-c?

Purgo Labs stocks it as “MOTS-c”; code usapeptidevendors takes 25% off at checkout. This page also lists the best-documented second vendor from our 112-vendor directory.

Is research-grade MOTS-c for human use?

No. Vendor material is sold for Research Use Only, not for human or veterinary use.